diff --git a/src/pretix/base/services/mail.py b/src/pretix/base/services/mail.py
index f706576fb7..74d5ec212b 100644
--- a/src/pretix/base/services/mail.py
+++ b/src/pretix/base/services/mail.py
@@ -98,7 +98,7 @@ def mail(email: str, subject: str, template: Union[str, LazyI18nString],
             htmlctx['event'] = event
             htmlctx['color'] = event.settings.primary_color
 
-            if event.settings.mail_from == settings.DEFAULT_FROM_EMAIL and event.settings.contact_mail:
+            if event.settings.mail_from == settings.DEFAULT_FROM_EMAIL and event.settings.contact_mail and not headers.get('Reply-To'):
                 headers['Reply-To'] = event.settings.contact_mail
 
             prefix = event.settings.get('mail_prefix')